Links Between Complement Activation and Thrombosis
نویسندگان
چکیده
منابع مشابه
Links between complement deficiency and apoptosis
Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of complement. C1q- and C4-deficient mice develop a lupus-like disease and exhibit impaired clearance of apoptotic cells. The autoantigens targeted in SLE have been localised to the surface of apoptotic cell...
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Endothelial injury is the central factor in the events leading to thrombotic microangiopathy (TMA); however, the mechanisms involved are not fully understood. Here we investigate the role of neutrophils (PMNs) and of complement activation in inducing microvascular damage and loss of thromboresistance in TMA associated with ADAMTS-13 deficiency. PMNs isolated during the acute phase of the diseas...
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Complement is an important effector pathway of innate stranded DNA antibodies was low, positive in only five immunity. In this review the role of complement in the of the 24 patients tested. pathogenesis of systemic lupus erythematosus (SLE) is Hereditary deficiency of C1s and C1r is rarer than described. There are important associations between that of C1q deficiency and, in the majority of ca...
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BACKGROUND Vascular endothelial cells (ECs) express and release protein components of the complement pathways, as well as secreting and anchoring ultra-large von Willebrand factor (ULVWF) multimers in long string-like structures that initiate platelet adhesion during hemostasis and thrombosis. The alternative complement pathway (AP) is an important non-antibody-requiring host defense system. Th...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-121113